Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity
نویسندگان
چکیده
منابع مشابه
Regulation of Notch Signaling Activity
Cell-cell signalling mediated by the receptor Notch is used widely across the metazoans to determine cell fate and regulate pattern formation. Notch signals via a conserved regulated intramembrane proteolysis. Recent analyses of the cell biology of the Notch receptor have identified several fundamental mechanisms that contribute to regulate Notch signaling activity in space and time.
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I am sorry to say that the outcome at this stage is not a positive one, and we can not offer to publish your manuscript. The referees vary significantly in their overall assessments (with referee 1 being the most positive, while referee 2 is clearly opposed to publication in EMBOJ). However, despite the disparate recommendations, they raise very similar issues with the manuscript. The weakness ...
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The X-Notch-1 receptor, and its putative ligand, X-Delta-1, are thought to mediate an inhibitory cell-cell interaction, called lateral inhibition, that limits the number of primary neurons that form in Xenopus embryos. The expression of Xenopus ESR-1, a gene related to Drosophila Enhancer of split, appears to be induced by Notch signaling during this process. To determine how the activation of ...
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The Notch (N) pathway defines an evolutionarily conserved cell signaling mechanism that governs cell fate choices through local cell interactions. The ankyrin repeat region of the Notch receptor is essential for signaling and has been implicated in the interactions between Notch and two intracellular elements of the pathway: Deltex (Dx) and Suppressor of Hairless (Su(H)). Here we examine direct...
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ژورنال
عنوان ژورنال: Genes
سال: 2020
ISSN: 2073-4425
DOI: 10.3390/genes11111315